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Sri Venkateswara Institute of Medical Sciences (SVIMS), Tirupati, Andhra Pradesh


About the Bioinformatics Centre
 

Since its inception on 10th March, 2007, the centre became a focal point for providing training, communication and computational facilities to the teachers, researchers and students of various medical specialties of the university and neighbouring institutions. The centre was further extended to develop a molecular modeling laboratory with HPZ800 workstation, SGI workstation, Schrodinger software 2013, Discovery Studio 2.0. Being a medical science institution, constant efforts have been made by the centre to implement Bioinformatics techniques in healthcare through collaborative works with medical specialties of our institute as well as pharmacy departments of neighbouring institutes.  SVIMS Bioinformatics centre is actively involved in teaching and research activities of post graduate courses in Bioinformatics at M.Sc. (15 seats) and Ph.D. (6 seats) level. Dr. T. Madhan Mohan, Advisor, BTISnet, New Delhi inaugurated molecular modelling Lab. Padma Bhushan Dr. Mrs. Manju Sharma, chaired second BIF executive committee meeting.

 
Area of Specialization:

Sequence analysis, Molecular modelling, Rational Drug Design, Reverse vaccinology, database development and medical informatics

 
Objectives
  • Promoting Biology teaching through Bioinformatics by Organizing National level workshops, continuing medical education (CME) programs, Guest lecturers.
  • Providing long term training (4-6 month) for M.Sc. Bioinformatics students and short term training (One month) for B. Tech Bioinformatics/ Biotechnology students for partial fulfilment of their degrees
  • Developing Bioinformatics human resource through M.Sc. and Ph.D. Bioinformatics program.
  • Formulating standard in silico protocol for rational drug design and reverse vaccinology techniques to design inhibitor molecules against several disease such as leptospirosis, endocarditis, meningitis, cancer, arthrosclerosis and Alzheimer’s disease.
  • Developing drug target and lead molecule databases.
 
Current area of research
 

Design of drug molecules and subunit vaccine candidates against diseases such as leptospirosis, endocarditis, meningitis, cancer, arthrosclerosis and Alzheimer’s disease.

Databases/applications developed
  • Database of Leptospira Drug target
  • Common drug target database infective endocarditis
  • Database of drug targets and inhibitor of bacterial meningitis
  • A database of selected cancer drug targets
 
Infrastructure facilities
 

Hardware: HPZ800 workstation, Sun microsystem workstation (as par with SGI), SERVER (High end) for Database/Application Server, SERVER (Medium) for Porxy & File Server, 36 GB Server, Laptop, Desktop Machines (33 no. working on both windows and Linux OS), LCD Projector, HP Laser jet 2420 PCL6 Printer, Laser Jet Pro400 color printer, Scanner (2no.), photo copier, 10 KVA UPS, Wipro LQ DX Gold Printer, Canon Printer, Local Network Connection, 2 Mbps internet connectivity from BSNL Dataone Broad band internet.
Software: Windows 8, Windows XP, Rad Hat Linux, Biolinux, Turbo C++, JAVA, Visual Studio professional 2005, Ms-SQL Server, Oracle 9i, Active Perl, MySQL, Kaspersky end point security
Bioinformatics Vendor licensed software: Schrodinger software suite 2013, Discovery studio 2.0
Academic licensed Bioinformatics software: AutoDock, DOCK, MODELLER, EMBOSS, PHYLIP, PAUP, PILE UP, TM4 Software Suite, Hex, Argus lab
Learning materials
BTIS library of 67 Bioinformatics book, Dissertations

Faculty members

Dr. A. Umamaheswari, Associate Professor and Coordinator of BIF, Headi/c, Department of Bioinformatics, SVIMS


Mr. Dibyabhaba Pradhan, Project Assistant, BIF-BTBI program.

 

Contacts

Dr. A. Umamaheswari, Associate Professor and Coordinator of BIF, Headi/c, Department of Bioinformatics, SVIMS University, Tirupati, Andhra Pradesh-517507
Email:  svims.btisnet@nic.in


About the Institution
 

Sri Venkateswara Institute of Medical Sciences (SVIMS) was established by Tirumala Tirupati Devasthanams, Tirupati, in the year 1993 to provide the most advanced medical care to the poor and the needy at an affordable cost and became University by State Act in the year 1995. The Department of Bioinformatics was established in the year, 2003 and the University is first of its kind to start post graduate course in Bioinformatics in the state of Andhra Pradesh.  SVIMS University is the only medical science institute to have a DBT sponsored BIF in South India.

 
Achievements at a glance
 
  • Research papers published : 23
  • Conference papers presented: 92
  • Best poster/paper presentation awards: 09
  • National workshops organized: 04
  • CME programs organized: 04
  • Guest lecturers organized: 12
  • M.Sc. Bioinformatics thesis completed: 105
  • M.Phil. Bioinformatics thesis completed: 01
  • PhD Bioinformatics thesis completed: 01
  • International travel fellowships received: 03
  • Senior Research fellowships in Bioinformatics: 03
  • Students selected in BCIL Bioinformatics training program: 19
 
Recent Publications

Priyadarshini V., Pradhan D., Munikumar M Swargam S., Umamaheswari A* and Rajasekhar D. (2014) Genome-based approaches to develop epitope-driven subunit vaccines against pathogens of infective endocarditis. Journal of Biomolecular Structure and Dynamics. DOI:10.1080/07391102.2013.79587.

Pradhan D.,Priyadarshini V., Munikumar M., Swargam S., Umamaheswari A*  and Aparna B (2014) Para-(benzoyl)-phenylalanine as a potential inhibitor against LpxC of Leptospira spp.: Homology modeling, docking and molecular dynamics study. Journal of Biomolecular Structure and Dynamics 32(2), 171-185

Priyadarshini V., Pradhan D., Munikumar M, Swargam S., Umamaheswari A*  and Rajasekhar D. (2013) In Silico drug targets for infectious endocarditis. Online Journal of Bioinformatics. 14(1):32-50. 

Mobeen A., Priyadarshini V., Pradhan D., Munikumar M., Swargam S. and Umamaheswari A*  (2013) Identification of potent inhibitors for β-secretase through structure based virtual screening and molecular dynamics simulations. Journal of Clinical and Scientific Research. 2(3):139-50.

Priyadarshini V., Pradhan D., Munikumar M., Swargam S., Umamaheswari A*  and Rajasekhar D (2013) Molecular modeling, docking and dynamics studies of biotin carboxyl carrier protein of acetyl-CoA carboxylase to discover potential inhibitors. Journal of Clinical and Scientific Research. 2(2):72-80.

Priyadarshini V., Pradhan D., Munikumar M., Swargam S. and Umamaheswari A*  (2013) Structure-based virtual screening towards identification of potential FabH inhibitors. Journal of Biomolecular Structure and Dynamics.31:sup1, 113-114. 

Pradhan D., Priyadarshini V., Munikumar M., Swargam S. and Umamaheswari A* (2013) Discovery of potent KdsA inhibitors of Leptospira interrogans through homology modeling, docking, and molecular dynamics simulations. Journal of Biomolecular Structure and Dynamics.31:sup1, 105.

Munikumar M., Priyadarshini V., Pradhan D., Swargam S. and Umamaheswari A*  (2013) T-cell vaccine design for Streptococcus pneumoniae: an in silico approach. Journal of Biomolecular Structure and Dynamics.31:sup1, 114-115. 

Munikumar M., Priyadarshini V., Pradhan D., Umamaheswari A*  and Vengamma B (2013) Computational approaches to identify common subunit vaccine candidates against bacterial meningitis. Interdisciplinary Sciences: Computational Life Sciences 5(2):155-164.

 

 
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