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PRESIDENCY COLLEGE, CHENNAI


About the Bioinformatics Centre
 

The Bioinformatics Infrastructure Facility (BIF) Centre at P.G & Research Department of Microbiology & Biotechnology, Presidency College, Chennai is the foremost among the Bioinformatics Infrastructure Facility center of DBT to be inaugurated on 28 March 2007. This Centre had been developed under the programme BTIS net by Department of Biotechnology (DBT), Govt. of India for the promotion of Biology Teaching through Bioinformatics (BTBI) and was inaugurated by Honourable Minister for Higher Education, Government of Tamil Nadu Dr. K. Ponmudi in the presence of Dr. T. Madhan Mohan, Adviser, Department of Biotechnology, Ministry of Science & Technology, Govt. of India New Delhi.

 

Area of Specialization:

Medical Microbiology & Designing, Discovery& Development of Drugs
 
Objectives
  • Supporting the teaching activities of Biology and its allied areas of the host institute in particular and the neighboring institutions in general.
  • Building of information resources, prepare databases of interest to its users and to develop relevant information handling tools and techniques.
  • Assessing the information requirements and organizing necessary infrastructure to provide information and computer support services to the users.
  • Establishing the linkages with BTISnet of DBT for sharing Information Resources and Expertise.
  • Organizing Training/Workshop for familiarizing the application of Bioinformatics in Biology teaching and learning activities.
 
Achievements at a glance

Workshops conducted

Since the inception of BIFC in 2007, Presidency college (Aut) ,the centre has organized seven  National Level workshops and one state level workshop  on Application of Bioinformatics in Drug Discovery and Drug Development  and their specific themes are as follows  National Workshop on Bioinformatics & Diversity Among Viruses, National workshop on Bioinformatics in the Development of Viral Vaccine, Bioinformatics of Microbial Diversity,  Pharmacogenomics , Bioinformatics in Applied Biology , Application of Bioinformatics in Drug discovery and Drug development, Bioinformatics in Drug discovery   and Drug development.
The State level workshop was conducted on Application of Bioinformatics to the college teachers by Bioinformatics Facility centre of DBT, Presidency College (Aut.) Chennai. National science day celebrations were conducted during 2007, 2008, 2009 & 2012 at Presidency College, Chennai.

 

Databases Presented

The centre also developed five comprehensive databases and presented at the various international conferences emphasizing the importance of Antibiotics. The following themes are
  • Essential features of Natural antibiotics of microbial origin with special emphasis on Bioinformatics aspects of the gene. (INCOB 2008 (Oct 20-22) at Taipei, China)
  • A comprehensive and an update semi-synthetic antibiotic database on essential features of  antibiotics of microbial origin and their genomic information (INCOB 2009 (Sept 7-11) at Singapore)
  • A comprehensive database on human and animal vaccines (INCOB 2010 (Sept 26-28) at Tokyo, Japan)
  • A unique comprehensive database on “Potential Antibiotics from flowering plants” that was presented in INCOB 2011(30th Nov-2nd Dec) at Kuala Lumpur, Malaysia
 
Current area of research

Drug designing and development targeting the Structural and Nonstructural genes of Mosquito borne viruses (Chikungunya and Dengue virus) by in silico analysis . Epitope prediction and structural validation studies are being carried out for Influenza virus, Epstein Barr virus, Human Papillomavirus, Human Herpes virus 1 and 3 for the identification of immunodominant region.

 
Database developed

The Centre has developed five unique databases namely

Natural Antibiotics

SALIENT FEATURES

  • Chemical name
  • Pharmacology
  • Dosage
  • Source
  • Susceptible organisms/Infections treated
  • Side effects
  • Genes expressed during the production of antibiotics
Semi Synthetic Antibiotics
SALIENT FEATURES
  • Chemical name
  • Pharmacology
  • Dosage
  • Source
  • Susceptible organisms/Infections treated
  • Side effects
  • Genes expressed during the production of antibiotics
Synthetic Antibiotics
SALIENT FEATURES
  • Chemical name
  • Pharmacology
  • Dosage
  • Source
  • Susceptible organisms/Infections treated
  • Side effects
  • Genes expressed during the production of antibiotics
Database on Human & Animal Vaccine
SALIENT FEATURES
  • Vaccine types
  • Etiology
  • Symptoms
  • Vaccine
  • Discovery
  • Administration and schedule
  • Side effects
  • Genomic information
Potential Antibiotics from Flowering Plants
SALIENT FEATURES
  • Source
  • Physico chemical properties
  • Studies on In vitro antiviral activity
  • Studies on invivo antiviral activity
  • Genomic information
  • Structure
  • Molecular properties
  • References


About the Institution
 

 
Presidency College, Chennai is the first one among the two foremost institutions on Higher education & Research established by the British India Government in 1840 and one among the top 10 colleges in India with International reputation on education & research. The institute is located in an enviable & prime location of central Chennai facing the second longest and beautiful Marina beach.  The institution has a vast campus area of 30.51 Acres of land inclusive of its marina ground & student’s hostels. The foremost University of Madras province namely the University of Madras was started in 1857, nearly 17 years after the formation of Presidency College. On this account this college in proudly nick named as “The Mother of Madras University”. It has been a premier and mother / grandmother institute in higher education for all the Universities of south India. A galaxy of illustrious personalities had their education at this college, inclusive of Nobel Prize winners Sir.C.V. Raman, Prof. Dr. Chandrasekar & the Abel laureate in Mathematics Dr.Srinivasa Varadhan .The institute has 24 U.G departments & P.G departments.
 
Forthcoming plans

Besides the general application of this centre for the benefit of the P.G & Research Scholars, in browsing the net to get update information on the subject of their interest in Biology & to infuse a sense of interest on the use and importance of Bioinformatics and utilization of Bioinformatics softwares, the BIF centre of Presidency College has chosen a globally important and relevant area of Application of Bioinformatics namely “Drug discovery & development”. Also to impart knowledge on Bioinformatics to teachers as well as P.G Students
As, the drug discovery & development needs an inter and multidisciplinary approach, the Present Bioinformatics Centre will try to bring together the activities of  highly reputed and relevant departments to Drug discovery & development of this institution namely the department of Microbiology & Biotechnology, Chemistry, Plant Biology, Biotechnology, Zoology & Statistics.
To conduct programme for higher secondary school students & teachers on Bioinformatics, focus the importance of Bioinformatics in Drug discovery & Drug development. This will popularize Bioinformatics and create an effective impression in the young minds, who are in the cross roads of choosing their professional career, to venture into Bioinformatics and also appreciate its role in Drug discovery & Drug development.
            To establish interconnectivity and exchange of information with other centres working on Drug discovery & development under BTIS net of DBT.

 
Inter Institutional collaborations

An MOU was signed with King Institute of Preventive Medicine on the development of viral vaccines

 
Infrastructure facilities
Computer and Communication Facility
SERVER(high end) for Database /Application server, SERVER (medium) for proxy & file server, Desktop PCs – 20, HP Laser 2840 Jet Printer, Desk jet Printer (HP). Samsung SCX-4521F, 7.5 KVA three phase online UPS - 2, LCD projection screen
Scientific software packages
CLC Combined Workbench EXOME™ Horizon
Statistical Software for data analysis (Sigma Plot-12).
Software packages
  • Windows 2003 Server Std R2 Eng OLP NL AE
  • Windows 2003 Server CAL Eng OLP NL User CAL AE
  • Windows 2003 Server Std R2 Media Kit
  • ISA Sever Std Edition 2006 Eng OLP NL AE 1 Processor
  • ISA Server Std Media Kit
  • Visual Studio Pro 2005 Eng OLP NL AE
  • Visual Studio Pro 2005 Media Kit
  • Office 2007 English OLP NL AE
  • Office 2007 Media Kit
  •  Norton Antivirus 2007 Single User
  •  Symantec Antivirus workstation and Academic license
  •  Media kit
  •  Vista Business Edition Upg OLP NL AE
  •  SQL Server Std Edition 2005 Eng OLP NL AE
  •  SQL Server CAL 2005 Eng OP NL AE
  •  SQL Server Std Edition 2005 Media Kit
  •  Red Hat Linux Enterprise Edition 4
  •  Kaspersky PURE
 
Recent publications

Priya RoosveltIndu Purushothaman, Rajarajan  S, Comparative study on the difference between the etiological agents of Chickenpox and Herpes Zoster by in vitro, molecular and in silico analysis" International Journal of Recent Scientific Research 2013;4(8):1225-1238.(Impact factor :3.00)

Priya Roosvelt, Indu Purushothaman, Rajarajan S, A proteomic analysis and structure validation of Hemagglutinin and Neuraminidase gene among the epidemic strains of H1N1”, International Journal of Current Research  2013; 5(8): 2135-2139.(Impact factor:1.125)

Priya Roosvelt, Indu Purushothaman, Rajarajan S, Screening of potential T cell antigenic determinants of Human Herpesvirus-1 (HSV-1): an Immunoinformatics study” International Journal of Pharmacy and Integrated Life Sciences 2013; 1(8):8-19 9.

C. Soundhari and Rajarajan S, In vitro screening of lyophilized extracts of Alpinia galanga and Oldenlandia umbellata for antimycobacterial activity. International Journal of Biological and Pharmaceutical Research 2013; 4(6): 427-432.(Impact Factor:1.04)

C. Soundhari and Rajarajan S, Determination of anti-tubercular activity of four Indian medicinal plants against Mycobacterium tuberculosis by broth micro dilution method.International Journal of Pharmaceutical Sciences and Research. 2013; 4 (10): 3932-3937  (Impact Factor: 0.861)

C. Soundhari and Rajarajan S, In vitro screening of lyophilised extracts of Solanum trilobatum and Tectona grandis for antitubercular activity. International Journal of Recent Scientific Research. 2013; 4(7):1018– 1021, July, 2013 (Impact Factor: 3.0)

C. Soundhari and Rajarajan S, Phenotypic and Genotypic Characterisation of isoniazid resistance in Mycobacterium tuberculosis. International Journal of Bio-Technology and Research, 2013; 3(3):43-52 (Impact Factor: 2.6531).

K. Kalaiyarasi, K. Sangeetha and S. Rajarajan, A comparative study on the microbial flora   of the fresh sap from   cut inflorescence and fermented sap (toddy) of Borrassus flabellifer Linn (Palmyrah tree) and of Cocos nucifera Linn (Coconut tree) to identify the microbial fermenters. International journal of research in pure and applied Microbiology. 2013; 3(3): 43-47.

K. Sangeetha, S. Madanraj and S. Rajarajan, A study on the microbiological quality of the packaged sprouts marketed in Chennai, Tamilnadu. International journal of recent scientific research. 2013; 4(7):998– 1000 (Impact Factor: 3.00)

Faculty Members

Coordinator:

Prof. Dr. S. Rajarajan, M.D., Ph.D., FIMSA., FABMS

Co-coordinator:

Dr. N. Arunagirinathan, M.Sc., M.Phil., B.Ed., Ph.D

Research Associate

Mr. J. Arunkumar, M.Sc., Ph.D

 

 

 

 

 

 

 

 

 

 

Contacts  
Prof. Dr. S. Rajarajan  

Coordinator
Bioinformatics Infrastructure Facility Centre of DBT
P.G & Research Dept. of Microbiology & Biotechnology
Presidency College (Autonomous)
No. 1, Kamarajar Salai, Chepauk
Chennai - 600 005
Tamil Nadu

 
Email

pcchennai.btisnet@nic.in, drsrajarajan@gmail.com

   
   
   
   
 
Website: www.bifcpresidency.tn.gov.in

 

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